Bootstrap uses flexible Grids.
Bootstrap includes a responsive, mobile first fluid grid system that appropriately scales up to 12 columns as the device or viewport size increases. It includes predefined classes for easy layout options.

Bootstrap Grid Documentation

RWD Frameworks
BootStrap and Foundation are two of the top frameworks.
Learn more about RWD
Where it all began! Also check out Mobile First by Luke Wroblewski and Responsive Web Design by Ethan Marcotte.
Grid Layout
Constructing the grid layout step by step.